Olaparib

For research use only. Not for therapeutic Use.

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Olaparib(Cat No.:I004823) is a poly (ADP-ribose) polymerase (PARP) inhibitor used as an anticancer agent, particularly in the treatment of cancers with BRCA1 or BRCA2 mutations, such as ovarian, breast, and prostate cancers. By inhibiting the PARP enzyme, Olaparib prevents the repair of single-strand DNA breaks, leading to the accumulation of DNA damage and ultimately causing cancer cell death. This mechanism is especially effective in cancer cells deficient in homologous recombination repair, such as those with BRCA mutations. Olaparib is used as part of targeted cancer therapy, and its ability to exploit the weaknesses in DNA repair mechanisms makes it a powerful tool in precision oncology.


Catalog Number I004823
CAS Number 763113-22-0
Synonyms

AZD2281; KU-0059436; KU0059436; AZD-2281; KU0059436; AZD 2281

Molecular Formula C₂₄H₂₃FN₄O₃
Purity ≥95%
Target PARP
Solubility DMSO: ≥ 34 mg/mL
Storage 3 years -20C powder
IC50 5 nM(PARP-1); 1 nM(PARP-2)
IUPAC Name 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one
InChI InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChIKey FDLYAMZZIXQODN-UHFFFAOYSA-N
SMILES C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

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