Oleandrin

• CAT Number: I003613
• CAS Number: 465-16-7
• Molecular Formula: C32H48O9
• Molecular Weight: 576.72
• Purity: ≥95%
• Target: Na+/K+ ATPase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: [(3S,5R,8R,9S,10S,13R,14S,16S,17R)-14-hydroxy-3-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate
• InChI: InChI=1S/C32H48O9/c1-17-29(35)24(37-5)14-27(39-17)41-21-8-10-30(3)20(13-21)6-7-23-22(30)9-11-31(4)28(19-12-26(34)38-16-19)25(40-18(2)33)15-32(23,31)36/h12,17,20-25,27-29,35-36H,6-11,13-16H2,1-5H3/t17-,20+,21-,22-,23+,24-,25-,27-,28-,29-,30-,31+,32-/m0/s1
• InChIKey: JLPDBLFIVFSOCC-XYXFTTADSA-N
• SMILES: C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3CC[C@]5([C@@]4(C[C@@H]([C@@H]5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O

Oleandrin(CAT: I003613) is a cardiac glycoside derived from the Nerium oleander plant, known for its potent inhibition of the Na+/K+-ATPase pump. This disruption of ionic gradients leads to increased intracellular calcium levels, enhancing cardiac contractility while also exhibiting cytotoxic effects in cancer cells. Oleandrin is particularly valuable in oncology and cardiovascular research, supporting studies on its dual role as a potential anticancer agent and a cardiac therapeutic. Its ability to modulate signaling pathways, including apoptosis and autophagy, makes Oleandrin a critical tool for investigating novel therapeutic approaches in cancer and heart failure management.