Oleanolic Acid

• CAT Number: I003807
• CAS Number: 508-02-1
• Molecular Formula: C30H48O3
• Molecular Weight: 456.7
• Purity: ≥95%
• Synonyms: Caryophyllin
• Solubility: DMSO: ≥ 4.8 mg/mL
• Storage: -20°C
• InChI: InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1
• InChIKey: MIJYXULNPSFWEK-GTOFXWBISA-N
• SMILES: CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])C1

Oleanolic acid (CAT: I003807) is a natural triterpenoid with diverse pharmacological actions. It exerts its effects by targeting various signaling pathways involved in inflammation, oxidative stress, and cancer progression. Oleanolic acid has been shown to inhibit NF-κB, Nrf2, and PI3K/Akt pathways, leading to anti-inflammatory, antioxidant, and anticancer activities. It has demonstrated potential as a therapeutic agent for inflammatory diseases, cancer, and liver disorders due to its ability to modulate key molecular targets. Oleanolic acid’s wide-ranging applications include anti-inflammatory treatments, chemoprevention and chemotherapy for cancer, and hepatoprotective interventions.

Reference

1: Dean PD, Halsall TG, Whitehouse MW. The preparation of some derivatives of
glycyrrhetic acid and oleanolic acid. J Pharm Pharmacol. 1967 Oct;19(10):682-9.
PubMed PMID: 4383583.

2: SILVA M, MANCINELLI P. Oleanolic acid in Lardizabala biternata. J Pharm Sci.
1961 Nov;50:975. PubMed PMID: 14039276.

3: ROWE EJ, ORR JE, et al. Isolation of oleanolic acid and ursolic acid from
Thymus vulgaris, L. J Am Pharm Assoc Am Pharm Assoc. 1949 Mar;38(3 Pt. 1):122-4.
PubMed PMID: 18116681.