For research use only. Not for therapeutic Use.
<p>Oligomycin A: a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase. Practically free of homologs</p>
| Catalog Number | R042533 |
| CAS Number | 579-13-5 |
| Synonyms | (1R,2’R,4E,5’S,6S,6’S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-Ethyl-3’,4’,5’,6’-tetrahydro-7,11,14,15-tetrahydroxy-6’-[(2R)-2-hydroxypropyl]-5’,6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene- |
| Molecular Formula | C45H74O11 |
| Purity | ≥95% |
| Target | ATPase |
| Solubility | >9.9mg/mL in DMSO |
| Storage | 3 years -20C powder |
| InChIKey | MNULEGDCPYONBU-WMBHJXFZSA-N |
| Reference | Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N., et al. , Proc. Natl Acad. Sci. U. S. A., 2006, 103, 1727.<br/><br/>Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K. K., et al. , Proc. Natl Acad. Sci. U. S. A., 2001, 98, 1717.<br/><br/>The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M. E., et al. , Cell Death Differ., 2000, 7, 338.</span></p> |
