For research use only. Not for therapeutic Use.
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Olopatadine Hydrochloride(cas 140462-76-6) is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively).
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<p>
It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg).1,2 Olopatadine is effective in treating allergic rhinitis and conjunctivitis.
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| Catalog Number | A000345 |
| CAS Number | 140462-76-6 |
| Synonyms | NA |
| Molecular Formula | C21H23NO3 • HCl |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
| Related CAS | 113806-05-6(free base) |
| IC50 | Ki = 16-41.1 nM |
| InChIKey | HVRLZEKDTUEKQH-NOILCQHBSA-N |
| SMILES | CN(C)CC/C=C1C2=C(C=CC=C2)COC3=CC=C(CC(O)=O)C=C3/1.Cl |
| Reference | 1: Torkildsen G, Narvekar A, Bergmann M. Efficacy and safety of olopatadine |
