Olprinone

• CAT Number: I000326
• CAS Number: 106730-54-5
• Molecular Formula: C14H10N4O
• Molecular Weight: 250.26
• Purity: ≥95%
• Synonyms: 5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
• Target: Phosphodiesterase (PDE)
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

Olprinone (CAT: I000326), also known as Loprinone, is a selective inhibitor of phosphodiesterase 3 (PDE3). By inhibiting PDE3, Olprinone prevents the breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in cells. This leads to increased intracellular levels of cAMP and cGMP, which in turn can have various pharmacological effects. Olprinone is primarily used as an inotropic agent and vasodilator in the treatment of heart failure and pulmonary hypertension. Its inhibition of PDE3 activity results in positive inotropic effects and vasodilation, contributing to improved cardiac function and reduced vascular resistance.

Reference

[1]. Tsubokawa T, Ishizuka S, Fukumoto K, et al. The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone. J Anesth. 2012 .
[2]. Mokra D, Drgova A, Pullmann R Sr, et al. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22.
[3]. Yamanaka H, Hayashi Y, Kamibayashi T, Mashimo T. Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass. J Cardiovasc Pharmacol. 2011 May;57(5):579-83.
[4]. Mazzon E, Esposito E, Di Paola R, et al. Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. Pharmacol Res. 2011 Jul;64(1):68-79.