For research use only. Not for therapeutic Use.
Omidenepag isopropyl（Cat No.:I017245）is a selective prostaglandin EP2 receptor agonist used for the treatment of glaucoma and ocular hypertension. By activating EP2 receptors, it increases aqueous humor outflow, effectively lowering intraocular pressure (IOP), a key factor in preventing optic nerve damage and vision loss in glaucoma patients. Omidenepag isopropyl offers an alternative to traditional prostaglandin analogs, with a distinct mechanism that provides effective IOP reduction. Its safety profile and efficacy make it a valuable therapeutic option for managing elevated IOP in patients with glaucoma or ocular hypertension.
| Catalog Number | I017245 |
| CAS Number | 1187451-19-9 |
| Synonyms | propan-2-yl 2-[[6-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]pyridin-2-yl]amino]acetate |
| Molecular Formula | C26H28N6O4S |
| Purity | 98% |
| Target | PTGER2 |
| Target Protein | |
| Appearance | Solid |
| Storage | Dry, dark and at 2 - 8 °C for six months or -20°C for two years. |
| IUPAC Name | propan-2-yl 2-[[6-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]pyridin-2-yl]amino]acetate |
| InChI | InChI=1S/C26H28N6O4S/c1-20(2)36-26(33)17-28-25-8-3-6-22(30-25)19-31(37(34,35)24-7-4-13-27-16-24)18-21-9-11-23(12-10-21)32-15-5-14-29-32/h3-16,20H,17-19H2,1-2H3,(H,28,30) |
| InChIKey | VIQCWEGEHRBLAC-UHFFFAOYSA-N |
| SMILES | CC(C)OC(=O)CNC1=CC=CC(=N1)CN(CC2=CC=C(C=C2)N3C=CC=N3)S(=O)(=O)C4=CN=CC=C4 |
| Reference | [1]. Kirihara T, et al. Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):145-153. [2]. Fuwa M, et al. Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys. J Ocul Pharmacol Ther. 2018 Sep;34(7):531-537. |
