For research use only. Not for therapeutic Use.
Omzotirome (TRC150094), a functional analog of iodothyronines, can be used for the research of hyperlipidaemia (WO2008149379)[1][2].
Omzotirome (0.750 mg/ 100 g; i.p.) with high-fat diet rats have significantly less visceral adipose tissue (vs. HFD rats) and exhibit altered metabolism in two major tissues that are very active metabolically and exhibit increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats[1].
Omzotirome, a functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet (HFD)[1].
| Catalog Number | I033881 |
| CAS Number | 1092551-88-6 |
| Synonyms | 3-[4-[(7-hydroxy-6-methyl-2,3-dihydro-1H-inden-4-yl)methyl]-3,5-dimethylpyrazol-1-yl]propanoic acid |
| Molecular Formula | C19H24N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H24N2O3/c1-11-9-14(15-5-4-6-16(15)19(11)24)10-17-12(2)20-21(13(17)3)8-7-18(22)23/h9,24H,4-8,10H2,1-3H3,(H,22,23) |
| InChIKey | OFUOCIUIWKDKPA-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C2CCCC2=C1O)CC3=C(N(N=C3C)CCC(=O)O)C |
| Reference | [1]. WO2008149379 [2]. Cioffi F, et al. TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet. FASEB J. 2010;24(9):3451-3461. |
