For research use only. Not for therapeutic Use.
ON123300（Cat No.:I001387）is a selective inhibitor of the phosphoinositide 3-kinase (PI3K) pathway, specifically targeting the PI3K gamma isoform. This compound shows significant promise in preclinical studies for its potential to modulate immune responses and combat inflammatory diseases. By inhibiting PI3K gamma, ON123300 may enhance antitumor immunity and improve therapeutic outcomes in cancer treatment. Its unique mechanism of action allows for targeted intervention in various disease models, making it a valuable asset in drug development. Ongoing research continues to explore its efficacy and safety profile in clinical settings.
| Catalog Number | I001387 |
| CAS Number | 1357470-29-1 |
| Synonyms | 8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile |
| Molecular Formula | C24H27N7O |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 3.8 nM |
| IUPAC Name | 8-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)anilino]-7-oxopyrido[2,3-d]pyrimidine-6-carbonitrile |
| InChI | InChI=1S/C24H27N7O/c1-29-10-12-30(13-11-29)20-8-6-19(7-9-20)27-24-26-16-18-14-17(15-25)23(32)31(22(18)28-24)21-4-2-3-5-21/h6-9,14,16,21H,2-5,10-13H2,1H3,(H,26,27,28) |
| InChIKey | VADOZMZXXRBXNY-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C=C(C(=O)N(C4=N3)C5CCCC5)C#N |
| Reference | </br>1:Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Perumal D, Kuo PY, Leshchenko VV, Jiang Z, Divakar SK, Cho HJ, Chari A, Brody J, Reddy MV, Zhang W, Reddy EP, Jagannath S, Parekh S.Cancer Res. 2016 Mar 1;76(5):1225-36. doi: 10.1158/0008-5472.CAN-15-2934. Epub 2016 Feb 12. PMID: 26873845 Free Article</br>2:Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. Divakar SK, Ramana Reddy MV, Cosenza SC, Baker SJ, Perumal D, Antonelli AC, Brody J, Akula B, Parekh S, Reddy EP.Leukemia. 2016 Jan;30(1):86-93. doi: 10.1038/leu.2015.185. Epub 2015 Jul 15. PMID: 26174628 Free PMC Article</br>3:Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor models. Zhang X, Lv H, Zhou Q, Elkholi R, Chipuk JE, Reddy MV, Reddy EP, Gallo JM.Mol Cancer Ther. 2014 May;13(5):1105-16. doi: 10.1158/1535-7163.MCT-13-0847. Epub 2014 Feb 25. PMID: 24568969 Free PMC Article |
