Ondansetron

For research use only. Not for therapeutic Use.

  • CAT Number: A000976
  • CAS Number: 99614-02-5
  • Molecular Formula: C18H19N3O
  • Molecular Weight: 293.37
  • Purity: ≥95%
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This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body/’s natural substances (serotonin) that causes vomiting.


Catalog Number A000976
CAS Number 99614-02-5
Synonyms

99614-02-5; Zofran; Zophren; Zudan; Zofran ODT

Molecular Formula C18H19N3O
Purity ≥95%
Target Neuronal Signaling
Solubility Limited solubility
Storage -20°C
IUPAC Name 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
InChIKey FELGMEQIXOGIFQ-UHFFFAOYSA-N
SMILES CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
Reference

1: Chu LF, Rico T, Cornell E, Obasi H, Encisco EM, Vertelney H, Gamble JG,
Crawford CW, Sun J, Clemenson A, Erlendson MJ, Okada R, Carroll I, Clark JD.
Ondansetron does not prevent physical dependence in patients taking opioid
medications chronically for pain control. Drug Alcohol Depend. 2017 Aug
14;183:176-183. doi: 10.1016/j.drugalcdep.2017.06.043. [Epub ahead of print]
PubMed PMID: 29278818.

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2: Lee DY, Trinh T, Roy SK. Torsades de Pointes after Ondansetron Infusion in 2
Patients. Tex Heart Inst J. 2017 Oct 1;44(5):366-369. doi: 10.14503/THIJ-16-6040.
eCollection 2017 Oct. PubMed PMID: 29259513; PubMed Central PMCID: PMC5731596.
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3: Karacaer F, Biricik E, ünal &#304;, Büyükkurt S, ünlügen&#231; H. Does prophylactic
ondansetron reduce norepinephrine consumption in patients undergoing cesarean
section with spinal anesthesia? J Anesth. 2017 Dec 14. doi:
10.1007/s00540-017-2436-x. [Epub ahead of print] PubMed PMID: 29243058.

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4: Maitra A, Bhattacharyya S, Paik S, Pathak P, Tripathi SK. A Rare Case of Fixed
Drug Eruption due to Ondansetron. Iran J Med Sci. 2017 Sep;42(5):497-500. PubMed
PMID: 29234184; PubMed Central PMCID: PMC5722969.
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5: Fejzo MS, MacGibbon KW, Mullin PM. Critique of inaccurate reporting in
Edlavitch article on /Publishing negative findings and the challenge of avoiding
type II errors in studies of suspect teratogens: Example of a recent ondansetron
publication/. Reprod Toxicol. 2017 Nov 22. pii: S0890-6238(17)30063-1. doi:
10.1016/j.reprotox.2017.11.007. [Epub ahead of print] PubMed PMID: 29174065.
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6: Gray JM, Maewal JD, Lunos SA, Furnival RA, Hendrickson MA. Ondansetron
Prescription for Home Use in a Pediatric Emergency Department. Pediatr Emerg
Care. 2017 Nov 14. doi: 10.1097/PEC.0000000000001343. [Epub ahead of print]
PubMed PMID: 29135900.
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7: Hagbom M, Novak D, Ekstr&#246;m M, Khalid Y, Andersson M, Lindh M, Nordgren J,
Svensson L. Ondansetron treatment reduces rotavirus symptoms-A randomized
double-blinded placebo-controlled trial. PLoS One. 2017 Oct 27;12(10):e0186824.
doi: 10.1371/journal.pone.0186824. eCollection 2017. PubMed PMID: 29077725;
PubMed Central PMCID: PMC5659648.
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8: Green-Hopkins I, Monuteaux MC, Lee L, Nigrovic L, Mannix R, Schutzman S. Use
of Ondansetron for Vomiting After Head Trauma: Does It Mask Clinically
Significant Traumatic Brain Injury? Pediatr Emerg Care. 2017 Oct 16. doi:
10.1097/PEC.0000000000001315. [Epub ahead of print] PubMed PMID: 29040247.
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9: Ortiz-Gómez JR, Palacio-Abizanda FJ, Morillas-Ramirez F, Fornet-Ruiz I,
Lorenzo-Jiménez A, Bermejo-Albares ML. Reducing by 50% the incidence of maternal
hypotension during elective caesarean delivery under spinal anesthesia: Effect of
prophylactic ondansetron and/or continuous infusion of phenylephrine – a
double-blind, randomized, placebo controlled trial. Saudi J Anaesth. 2017
Oct-Dec;11(4):408-414. doi: 10.4103/sja.SJA_237_17. PubMed PMID: 29033720; PubMed
Central PMCID: PMC5637416.
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10: Hoffman RJ, Alansari K. Effect of intravenous ondansetron on QTc interval in
children with gastroenteritis. Am J Emerg Med. 2017 Oct 4. pii:
S0735-6757(17)30806-9. doi: 10.1016/j.ajem.2017.10.004. [Epub ahead of print]
PubMed PMID: 29029798.

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