ONL-1204

For research use only. Not for therapeutic Use.

  • CAT Number: I033885
  • CAS Number: 2040964-58-5
  • Molecular Formula: C71H100N18O16
  • Molecular Weight: 1461.69
  • Purity: 98%
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ONL-1204(CAT: I033885) is a small-molecule inhibitor targeting the CD95 antigen (Fas), a key receptor involved in apoptosis signaling. By inhibiting CD95, ONL-1204 prevents the activation of Fas-mediated cell death pathways, offering potential therapeutic applications in conditions where excessive apoptosis contributes to disease progression, such as retinal degenerative disorders and neurodegeneration. This compound is particularly relevant in cell death and neuroprotection research, where it aids in exploring strategies to mitigate apoptotic damage and preserve cellular function. Its specificity as a Fas inhibitor makes it a valuable tool for advancing therapeutic approaches in apoptosis-related diseases.


Catalog Number I033885
CAS Number 2040964-58-5
Synonyms

ONL-1204; ONL1204; ONL 1204

Molecular Formula C71H100N18O16
Purity 98%
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (S)-2-((2S,5S,11S,14S,17S,20S,23S)-20-((1H-imidazol-4-yl)methyl)-23-amino-17-((S)-sec-butyl)-14-(4-hydroxybenzyl)-24-(1H-imidazol-4-yl)-11-isobutyl-2-isopropyl-5-methyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-N1-((S)-1-(((2S,3S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)succinamide
InChI InChI=1S/C71H100N18O16/c1-10-38(7)59(70(104)81-50(61(74)95)25-41-12-18-46(90)19-13-41)88-67(101)53(27-43-16-22-48(92)23-17-43)84-66(100)55(30-56(73)93)86-69(103)58(37(5)6)87-62(96)40(9)80-57(94)33-77-64(98)51(24-36(3)4)83-65(99)52(26-42-14-20-47(91)21-15-42)85-71(105)60(39(8)11-2)89-68(102)54(29-45-32-76-35-79-45)82-63(97)49(72)28-44-31-75-34-78-44/h12-23,31-32,34-40,49-55,58-60,90-92H,10-11,24-30,33,72H2,1-9H3,(H2,73,93)(H2,74,95)(H,75,78)(H,76,79)(H,77,98)(H,80,94)(H,81,104)(H,82,97)(H,83,99)(H,84,100)(H,85,105)(H,86,103)(H,87,96)(H,88,101)(H,89,102)/t38-,39-,40-,49-,50-,51-,52-,53-,54-,55-,58-,59-,60-/m0/s1
InChIKey MDQMJABKOUZYGG-QZJYLVOGSA-N
SMILES CC[C@@H]([C@@H](C(N[C@H](C(N)=O)Cc1ccc(O)cc1)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@H](Cc2nc[nH]c2)N)=O)Cc3nc[nH]c3)=O)=O)Cc4ccc(O)cc4)=O)CC(C)C)=O)=O)C)=O)=O)CC(N)=O)=O)Cc5ccc(O)cc5)=O)C

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