For research use only. Not for therapeutic Use.
ONL-1204 is a small molecule, CD95 antigen inhibitor (Fas inhibitor) being developed by ONL Therapeutics for the treatment of retinal detachment.
| Catalog Number | I033885 |
| CAS Number | 2040964-58-5 |
| Synonyms | ONL-1204; ONL1204; ONL 1204 |
| Molecular Formula | C71H100N18O16 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-2-((2S,5S,11S,14S,17S,20S,23S)-20-((1H-imidazol-4-yl)methyl)-23-amino-17-((S)-sec-butyl)-14-(4-hydroxybenzyl)-24-(1H-imidazol-4-yl)-11-isobutyl-2-isopropyl-5-methyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-N1-((S)-1-(((2S,3S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)succinamide |
| InChI | InChI=1S/C71H100N18O16/c1-10-38(7)59(70(104)81-50(61(74)95)25-41-12-18-46(90)19-13-41)88-67(101)53(27-43-16-22-48(92)23-17-43)84-66(100)55(30-56(73)93)86-69(103)58(37(5)6)87-62(96)40(9)80-57(94)33-77-64(98)51(24-36(3)4)83-65(99)52(26-42-14-20-47(91)21-15-42)85-71(105)60(39(8)11-2)89-68(102)54(29-45-32-76-35-79-45)82-63(97)49(72)28-44-31-75-34-78-44/h12-23,31-32,34-40,49-55,58-60,90-92H,10-11,24-30,33,72H2,1-9H3,(H2,73,93)(H2,74,95)(H,75,78)(H,76,79)(H,77,98)(H,80,94)(H,81,104)(H,82,97)(H,83,99)(H,84,100)(H,85,105)(H,86,103)(H,87,96)(H,88,101)(H,89,102)/t38-,39-,40-,49-,50-,51-,52-,53-,54-,55-,58-,59-,60-/m0/s1 |
| InChIKey | MDQMJABKOUZYGG-QZJYLVOGSA-N |
| SMILES | CC[C@@H]([C@@H](C(N[C@H](C(N)=O)Cc1ccc(O)cc1)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@H](Cc2nc[nH]c2)N)=O)Cc3nc[nH]c3)=O)=O)Cc4ccc(O)cc4)=O)CC(C)C)=O)=O)C)=O)=O)CC(N)=O)=O)Cc5ccc(O)cc5)=O)C |
| Reference | 1: Krishnan A, Kocab AJ, Zacks DN, Marshak-Rothstein A, Gregory-Ksander M. A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma. J Neuroinflammation. 2019 Sep 30;16(1):184. doi: 10.1186/s12974-019-1576-3. PMID: 31570110; PMCID: PMC6767653. |
