For research use only. Not for therapeutic Use.
ONO-2952 is a peripheral benzodiazepine receptor antagonist potentially for the treatment of irritable bowel syndrome.
| Catalog Number | I008459 |
| CAS Number | 895169-20-7 |
| Synonyms | ONO-2952; ONO2952; ONO 2952;(S)-1-(1/’-(4-chloro-2-methoxyphenyl)-5/’-fluoro-1/’,9/’-dihydrospiro[cyclopropane-1,4/’-pyrido[3,4-b]indol]-2/'(3/’H)-yl)ethan-1-one |
| Molecular Formula | C22H20ClFN2O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | CC(N(C[15:S=N]HC[19]()=CC=C(Cl)C=C@19OC)CC[2](C[7]()=C(@15)NC[14]=C@8C(F)=CC=C@14)CC@3)=O |
| InChIKey | ZBQMTQGDBFZUBG-NRFANRHFSA-N |
| SMILES | CC(N([C@H]1C2=CC=C(Cl)C=C2OC)CC3(C4=C1NC5=C4C(F)=CC=C5)CC3)=O |
| Reference | </br>1:Editorial: ONO-2952 in irritable bowel syndrome with diarrhoea – authors/’ reply. Whitehead WE, Duffy K, Sharpe J, Nabata T, Bruce M.Aliment Pharmacol Ther. 2017 Apr;45(7):1005. doi: 10.1111/apt.13957. No abstract available. PMID: 28256085 </br>2:Editorial: ONO-2952 in irritable bowel syndrome with diarrhoea. Nee J, Lembo A.Aliment Pharmacol Ther. 2017 Apr;45(7):1004-1005. doi: 10.1111/apt.13920. No abstract available. PMID: 28256084 </br>3:Brain translocator protein occupancy by ONO-2952 in healthy adults: A Phase 1 PET study using [<sup>11</sup> C]PBR28. Frankle WG, Narendran R, Wood AT, Suto F, Himes ML, Kobayashi M, Ohno T, Yamauchi A, Mitsui K, Duffy K, Bruce M.Synapse. 2017 Feb 28. doi: 10.1002/syn.21970. [Epub ahead of print] PMID: 28245513 </br>4:Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography. Mitsui K, Morimoto N, Niwa T, Yamaura Y, Ohba H, Tsukada H, Katsumata S.J Pharmacol Exp Ther. 2017 Mar;360(3):457-465. doi: 10.1124/jpet.116.238568. Epub 2016 Dec 16. PMID: 27986860 </br>5:Randomised clinical trial: exploratory phase 2 study of ONO-2952 in diarrhoea-predominant irritable bowel syndrome. Whitehead WE, Duffy K, Sharpe J, Nabata T, Bruce M.Aliment Pharmacol Ther. 2017 Jan;45(1):14-26. doi: 10.1111/apt.13839. Epub 2016 Nov 7. PMID: 27910150 Free PMC Article</br>6:Safety, Tolerability, and Pharmacokinetic Profile of the Novel Translocator Protein 18 kDa Antagonist ONO-2952 in Healthy Volunteers. Suto F, Wood AT, Kobayashi M, Komaba J, Duffy K, Bruce M.Clin Ther. 2015 Sep;37(9):2071-84. doi: 10.1016/j.clinthera.2015.07.010. Epub 2015 Aug 4. PMID: 26249232 Free Article</br>7:Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats. Mitsui K, Niwa T, Kawahara Y, Morimoto N, Ohmoto K, Kato M, Yamaura Y, Yoshimoto N, Suna H, Katsumata S.Neuropharmacology. 2015 Dec;99:51-66. doi: 10.1016/j.neuropharm.2015.07.011. Epub 2015 Jul 17. PMID: 26189762 |
