For research use only. Not for therapeutic Use.
ONO-4059 hydrochloride(Cat No.:I001695)is a potent and selective inhibitor of Bruton’s tyrosine kinase (BTK), a key enzyme in B-cell receptor signaling. By inhibiting BTK, ONO-4059 blocks the activation and proliferation of B-cells, making it a valuable compound for research on B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma. Its specificity for BTK also makes it a potential therapeutic agent in autoimmune diseases like rheumatoid arthritis. ONO-4059 is crucial for exploring targeted therapies in cancer and immune-mediated disorders.
Catalog Number | I001695 |
CAS Number | 1439901-97-9 |
Molecular Formula | C25H23ClN6O3 |
Purity | ≥95% |
Target | target:BTK. |
Solubility | 10 mM in DMSO |
Storage | Store at -20°C |
IUPAC Name | 6-amino-9-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one;hydrochloride |
InChI | InChI=1S/C25H22N6O3.ClH/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19;/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28);1H/t18-;/m1./s1 |
InChIKey | UQYDCIJFACDXSG-GMUIIQOCSA-N |
SMILES | CC#CC(=O)N1CC[C@H](C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl |
Reference | <p style=/line-height:25px/> <br>[2]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59. </p> |