ONO-4059 hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I001695
  • CAS Number: 1439901-97-9
  • Molecular Formula: C25H23ClN6O3
  • Molecular Weight: 490.94
  • Purity: ≥95%
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ONO-4059 hydrochloride(Cat No.:I001695)is a potent and selective inhibitor of Bruton’s tyrosine kinase (BTK), a key enzyme in B-cell receptor signaling. By inhibiting BTK, ONO-4059 blocks the activation and proliferation of B-cells, making it a valuable compound for research on B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma. Its specificity for BTK also makes it a potential therapeutic agent in autoimmune diseases like rheumatoid arthritis. ONO-4059 is crucial for exploring targeted therapies in cancer and immune-mediated disorders.


Catalog Number I001695
CAS Number 1439901-97-9
Molecular Formula C25H23ClN6O3
Purity ≥95%
Target target:BTK.
Solubility 10 mM in DMSO
Storage Store at -20°C
IUPAC Name 6-amino-9-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one;hydrochloride
InChI InChI=1S/C25H22N6O3.ClH/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19;/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28);1H/t18-;/m1./s1
InChIKey UQYDCIJFACDXSG-GMUIIQOCSA-N
SMILES CC#CC(=O)N1CC[C@H](C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N.Cl
Reference

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<br>[1]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419

<br>[2]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59.

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