For research use only. Not for therapeutic Use.
ONT-093 (Cat.No:I008470), also known as OC-144-093, is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. OC144-093 is the least non-specifically toxic Pgp inhibitor described to date, with an average cytostatic IC50 of >60 microM in 15 cell types. OC144-093 may represent an ideal candidate for use in enhancement of AED blood-brain barrier penetration.
| Catalog Number | I008470 |
| CAS Number | 216227-54-2 |
| Synonyms | ONT-093; ONT 093; ONT093; OC-144-093; OC 144-093; OC144-093; OC-144093; OC 144093; OC144093.;(E)-4,4/’-(2-(4-(3-ethoxyprop-1-en-1-yl)phenyl)-1H-imidazole-4,5-diyl)bis(N-isopropylaniline) |
| Molecular Formula | C32H38N4O |
| Purity | ≥95% |
| Target | P-glycoprotein |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 4-[2-[4-[(E)-3-ethoxyprop-1-enyl]phenyl]-4-[4-(propan-2-ylamino)phenyl]-1H-imidazol-5-yl]-N-propan-2-ylaniline |
| InChI | InChI=1S/C32H38N4O/c1-6-37-21-7-8-24-9-11-27(12-10-24)32-35-30(25-13-17-28(18-14-25)33-22(2)3)31(36-32)26-15-19-29(20-16-26)34-23(4)5/h7-20,22-23,33-34H,6,21H2,1-5H3,(H,35,36)/b8-7+ |
| InChIKey | RSJCLODJSVZNQA-BQYQJAHWSA-N |
| SMILES | CCOCC=CC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=C(C=C3)NC(C)C)C4=CC=C(C=C4)NC(C)C |
| Reference | </br>1:A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer. Chi KN, Chia SK, Dixon R, Newman MJ, Wacher VJ, Sikic B, Gelmon KA.Invest New Drugs. 2005 Aug;23(4):311-5. PMID: 16012790 </br>2:Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093). Kuppens IE, Bosch TM, van Maanen MJ, Rosing H, Fitzpatrick A, Beijnen JH, Schellens JH.Cancer Chemother Pharmacol. 2005 Jan;55(1):72-8. Epub 2004 Aug 17. PMID: 15316750 </br>3:ONT-093 (Ontogen). Mistry P, Folkes A.Curr Opin Investig Drugs. 2002 Nov;3(11):1666-71. Review. PMID: 12476971 |
