Optovin

• CAT Number: I003276
• CAS Number: 348575-88-2
• Molecular Formula: C15H13N3OS2
• Molecular Weight: 315.41
• Purity: ≥95%
• Synonyms: (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• InChI: InChI=1S/C15H13N3OS2/c1-9-6-11(7-13-14(19)17-15(20)21-13)10(2)18(9)12-4-3-5-16-8-12/h3-8H,1-2H3,(H,17,19,20)/b13-7-
• InChIKey: YISGMOZSGOGYOU-QPEQYQDCSA-N
• SMILES: CC1=CC(=C(N1C2=CN=CC=C2)C)C=C3C(=O)NC(=S)S3

Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues[1].
Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM[1].
Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons[1].
Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1[1].
Optovin (1-10 μM) causes light-dependent motor excitation in vivo[1].
Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice[1].
Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish[1].

Reference

[1]. Kokel D, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63.
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