Orforglipron hemicalcium hydrate

• CAT Number: I040027
• CAS Number: 3008544-96-2
• Molecular Formula: C48H48F2N10O5.1/2Ca.H2O
• Molecular Weight: 921.02
• Purity: ≥95%

Orforglipron hemicalcium hydrate(Cat No.: I040027), also known as LY3502970 hemicalcium hydrate, is the hemicalcium salt form of Orforglipron, an orally active agonist of the glucagon-like peptide-1 receptor (GLP-1R). This compound has demonstrated efficacy in ameliorating type 2 diabetes by enhancing glucose-dependent insulin secretion and improving energy balance. In preclinical studies involving cynomolgus monkeys, Orforglipron hemicalcium hydrate effectively inhibited food intake, promoted insulin secretion, and reduced blood glucose levels in a dose-dependent manner. Its favorable pharmacokinetic profile supports its potential as a therapeutic agent for managing type 2 diabetes.

Reference

[1]. Pyrazolopyridine derivative having glp-1 receptor agonist effect. WO2018056453A1