Org 24598 lithium salt

• CAT Number: I010880
• CAS Number: 722456-08-8
• Molecular Formula: C19H19F3LiNO3
• Molecular Weight: 373.3
• Purity: ≥95%
• Synonyms: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine lithium salt
• Target: GlyT1
• Solubility: Soluble to 10 mM in water and to 5 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: lithium;2-[methyl-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino]acetate
• InChI: InChI=1S/C19H20F3NO3.Li/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22;/h2-10,17H,11-13H2,1H3,(H,24,25);/q;+1/p-1/t17-;/m1./s1
• InChIKey: VMQXVSNARQMSDL-UNTBIKODSA-M
• SMILES: [Li+].CN(CCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F)CC(=O)[O-]

Selective inhibitor of the glial glycine transporter (GlyT1) (pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively).