For research use only. Not for therapeutic Use.
Potent and selective GlyT-1 glycine transporter or reuptake inhibitor; a therapeutic intended for the treatment of neurological disorders
| Catalog Number | I008026 |
| CAS Number | 949588-40-3 |
| Molecular Formula | C21H25NO3.HCl |
| Purity | ≥95% |
| IUPAC Name | 2-[[(1R,2S)-6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl-methylamino]acetic acid;hydrochloride |
| InChI | InChI=1S/C21H25NO3.ClH/c1-22(14-20(23)24)13-17-9-8-16-12-18(25-2)10-11-19(16)21(17)15-6-4-3-5-7-15;/h3-7,10-12,17,21H,8-9,13-14H2,1-2H3,(H,23,24);1H/t17-,21+;/m1./s1 |
| SMILES | CN(C[C@H]1CCC2=C([C@H]1C3=CC=CC=C3)C=CC(=C2)OC)CC(=O)O.Cl |
| Reference | HH Lidoe et al. The glycine reuptake inhibitor Org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens. Alcoholism: Clin. Exp. Res. 2009, 33(7), 1151-1157.
K Morita et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J. Pharmacol. Exp. Ther. 2008, 326(2), 633-645.
A Molander et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats. Alcohol and Alcoholism (Oxford, United Kingdom) (2007), 42(1), 11-18.
K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Patents on CNS Drug Discovery, 2006, 1, 43-53. |
