For research use only. Not for therapeutic Use.
Org-34517 (Cat.No:I008029) is a chemical compound that acts as a selective antagonist of the serotonin 5-HT1B receptor. It has been studied for its potential applications in the treatment of migraines and other neurological disorders. Org-34517 has shown promising results in preclinical studies and may offer a targeted approach for managing these conditions.
| Catalog Number | I008029 |
| CAS Number | 189035-07-2 |
| Synonyms | Org-34517; SCH-900636; Org34517; SCH900636; Org 34517; SCH 900636;(8S,11R,13S,14S,17S)-11-(benzo[d][1,3]dioxol-5-yl)-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| Molecular Formula | C28H30O4 |
| Purity | ≥95% |
| Target | glucocorticoid receptor (GR) antagonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (8S,11R,13S,14S,17S)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one |
| InChI | InChI=1S/C28H30O4/c1-3-11-28(30)12-10-23-21-7-4-17-13-19(29)6-8-20(17)26(21)22(15-27(23,28)2)18-5-9-24-25(14-18)32-16-31-24/h5,9,13-14,21-23,30H,4,6-8,10,12,15-16H2,1-2H3/t21-,22+,23-,27-,28-/m0/s1 |
| InChIKey | DFELGYQKEOCHOA-BZAFBGKRSA-N |
| SMILES | CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC6=C(C=C5)OCO6)C)O |
| Reference | </br>1:Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic-pituitary-adrenal axis activation. Reynolds AR, Saunders MA, Brewton HW, Winchester SR, Elgumati IS, Prendergast MA.Drug Alcohol Depend. 2015 Sep 1;154:100-4. doi: 10.1016/j.drugalcdep.2015.06.018. Epub 2015 Jun 22. PMID: 26143299 Free PMC Article</br>2:Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line. Peeters BW, Ruigt GS, Craighead M, Kitchener P.Ann N Y Acad Sci. 2008 Dec;1148:536-41. doi: 10.1196/annals.1410.072. PMID: 19120154 |
