For research use only. Not for therapeutic Use.
Selective agonist of membrane progesterone receptor (mPR; IC50 value 33.9 nM). Org OD 02-0 mimics the protective effects of progestin hormones on serum starvation-induced cell death and apoptosis in both granulosa and breast cancer cells without altering caspase 3 activity. Org OD 02-0 significantly increased mitochondrial membrane potential (MMP) in serum starved MB468 cells.
KEYWORDS: Org OD 02-0 | supplier | mPR agonist | 19-CH2P4 | OrgOD02-0 | 19-CH2P4 | CAS [13258-85-0] | Progesterone | Progesterone (mPR) | Agonist | Receptors | Progestin | membrane | adipoQ | PAQR
| Catalog Number | M062205 |
| CAS Number | 13258-85-0 |
| Molecular Formula | C22H30O2 |
| Purity | ≥95% |
| IUPAC Name | (8S,9S,10S,13S,14S,17S)-17-acetyl-10-ethenyl-13-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| InChI | InChI=1S/C22H30O2/c1-4-22-12-9-16(24)13-15(22)5-6-17-19-8-7-18(14(2)23)21(19,3)11-10-20(17)22/h4,13,17-20H,1,5-12H2,2-3H3/t17-,18+,19-,20-,21+,22-/m0/s1 |
| SMILES | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C=C)C |
| Reference | J. Kelder et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative (…). Steroids. 2010, 75, 314-322.
G.E. Dressing et al. Membrane progesterone receptors (mPRs) mediate progestin induced antimorbidity in breast cancer cells and are expressed in human breast tumors. Horm. Cancer. 2012, 3, 101-112.
P. Thomas et al. Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells. Neuroendocrinology. 2012, 96, 162-171. List of publications using Org OD02-0 (Axon 2085) purchased from Axon Medchem |
