Oroxylin A

• CAT Number: I003686
• CAS Number: 480-11-5
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Sealed in dry,2-8°C
• IUPAC Name: 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
• InChI: InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3
• InChIKey: LKOJGSWUMISDOF-UHFFFAOYSA-N
• SMILES: COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=CC=C3)O

Oroxylin A（Cat No.:I003686）is a naturally occurring flavonoid derived from Scutellaria baicalensis, widely recognized for its therapeutic potential. This compound exhibits anti-inflammatory, antioxidant, and anticancer properties, making it a subject of interest in pharmaceutical research. Oroxylin A has been shown to modulate various signaling pathways, including those involved in apoptosis and immune response regulation. Additionally, it enhances cognitive function by inhibiting GABA(A) receptor activity, contributing to its neuroprotective effects. Its versatility makes Oroxylin A a promising candidate for drug development targeting cancer, neurological disorders, and inflammatory diseases.

Reference

[1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914

[2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10.

[3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9