ORP-101

• CAT Number: I033979
• CAS Number: 1820753-68-1
• Molecular Formula: C60H84N2O8
• Molecular Weight: 961.34
• Purity: 98%
• Synonyms: ORP-101; ORP101; ORP 101
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (2S)-2-[(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-11-[2-[[(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-yl]oxy]ethoxy]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-16-yl]-3,3-dimethylbutan-2-ol
• InChI: InChI=1S/C60H84N2O8/c1-51(2,3)53(7,63)41-31-55-19-21-59(41,65-9)49-57(55)23-25-61(33-35-11-12-35)43(55)29-37-15-17-39(47(69-49)45(37)57)67-27-28-68-40-18-16-38-30-44-56-20-22-60(66-10,42(32-56)54(8,64)52(4,5)6)50-58(56,46(38)48(40)70-50)24-26-62(44)34-36-13-14-36/h15-18,35-36,41-44,49-50,63-64H,11-14,19-34H2,1-10H3/t41-,42-,43-,44-,49-,50-,53+,54+,55-,56-,57+,58+,59-,60-/m1/s1
• InChIKey: LEQOVFCHMOTJKU-WJVXOHEGSA-N
• SMILES: C[C@]([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)OCCOC7=C8C9=C(C[C@@H]1[C@@]23[C@]9(CCN1CC1CC1)[C@@H](O8)[C@@](CC2)([C@H](C3)[C@@](C)(C(C)(C)C)O)OC)C=C7)O4)CC1CC1)OC)(C(C)(C)C)O

ORP-101(CAT: I033979) is a novel chemical entity designed to function as a partial μ-opioid receptor agonist and a full κ-opioid receptor antagonist. Its large and stable molecular structure enhances receptor specificity and pharmacological efficacy, making it a valuable tool in opioid receptor research. ORP-101 holds potential for therapeutic applications in managing pain, mood disorders, and gastrointestinal conditions without the full spectrum of side effects typically associated with opioid receptor modulation. With high purity and pharmacological stability, it is suitable for in vitro and in vivo studies, supporting advancements in opioid receptor-targeted drug discovery and therapeutic development.