Orteronel

• CAT Number: I006748
• CAS Number: 426219-18-3
• Molecular Formula: C18H17N3O2
• Molecular Weight: 307.35
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O

Orteronel(TAK-700) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). TAK-700 (Orteronel) is an androgen biosynthesis inhibitor. Phase 3.

Reference

[1] Kaku T, et al. Bioorg Med Chem. 2011, 19(21), 6383-6399.
[2] Yamaoka M, et al. J Steroid Biochem Mol Biol. 2012, 129(3-5), 115-128.