For research use only. Not for therapeutic Use.
OSMI-1 is a quinolinone-6-sulfonamide that inhibits <em>O</em>-GlcNAc transferase (OGT; IC<sub>50</sub> = 2.7 μM) <em>in vitro</em>. It is cell permeable and inhibits global <em>O</em>-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of <em>O</em>-GlcNAc residues and decreases levels of cellular <em>O</em>-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours.
| Catalog Number | R067051 |
| CAS Number | 1681056-61-0 |
| Synonyms | αR-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide |
| Molecular Formula | C28H25N3O6S2 |
| Purity | ≥95% |
| Target | Acyltransferase |
| Storage | -20°C |
| IUPAC Name | (2R)-N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-[(2-oxo-1H-quinolin-6-yl)sulfonylamino]-N-(thiophen-2-ylmethyl)acetamide |
| InChI | InChI=1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1 |
| InChIKey | IYIGLWQQAMROOF-HHHXNRCGSA-N |
| SMILES | COC1=CC=CC=C1C(C(=O)N(CC2=CC=CO2)CC3=CC=CS3)NS(=O)(=O)C4=CC5=C(C=C4)NC(=O)C=C5 |
| Reference | 1.Ortiz-Meoz, R.F.,Jiang, J.,Lazarus, M.B., et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 10(6), 1392-1397 (2015). |
