OSMI-4

• CAT Number: I019657
• CAS Number: 2260791-14-6
• Molecular Formula: C₂₇H₂₆ClN₃O₇S₂
• Molecular Weight: 604.09
• Purity: ≥95%
• Target: Acyltransferase
• IUPAC Name: ethyl 2-[[(2R)-2-[(7-chloro-2-oxo-1H-quinolin-6-yl)sulfonylamino]-2-(2-methoxyphenyl)acetyl]-(thiophen-2-ylmethyl)amino]acetate
• InChI: 1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1
• InChIKey: STPSLAZMEWZDAJ-AREMUKBSSA-N
• SMILES: CCOC(=O)CN(CC1=CC=CS1)C(=O)[C@@H](C2=CC=CC=C2OC)NS(=O)(=O)C3=C(C=C4C(=C3)C=CC(=O)N4)Cl

OSMI-4 (Cat No.: I019657) is a potent and selective inhibitor of O-GlcNAc transferase (OGT), an enzyme responsible for O-GlcNAcylation of proteins. By blocking OGT activity, OSMI-4 disrupts cellular processes linked to metabolism, signal transduction, and transcriptional regulation. It is widely used in cancer, neurodegenerative disease, and metabolic disorder research to explore the role of O-GlcNAcylation in disease progression. As a valuable tool compound, OSMI-4 aids in studying the therapeutic potential of targeting OGT for conditions involving dysregulated glucose metabolism and cellular signaling.

Reference

[1]. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 24;140(42):13542-13545.