For research use only. Not for therapeutic Use.
Osmundacetone is a natural product isolated from Osmundae Rhizoma, with neuroprotective and anti-apoptotic effects. Osmundacetone also has DPPH scavenging activity and anti-oxidative stress activity. Osmundacetone inhibits MAPK phosphorylation, including JNK, ERK, and p38 kinase. Osmundacetone can be a potential agent for the research of neurodegenerative diseases[1][2].
Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases[1].
| Catalog Number | I016753 |
| CAS Number | 37079-84-8 |
| Synonyms | (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one |
| Molecular Formula | C10H10O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H10O3/c1-7(11)2-3-8-4-5-9(12)10(13)6-8/h2-6,12-13H,1H3/b3-2+ |
| InChIKey | YIFZKRGUGKLILR-NSCUHMNNSA-N |
| SMILES | CC(=O)C=CC1=CC(=C(C=C1)O)O |
| Reference | [1]. D. Zhang, et al. Isolation and determination of osmundacetone in Osmundae Rhizoma. Journal of Chinese Pharmaceutical Sciences 45(21):1612-1614. [2]. Tuy An Trinh, et al. Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. Biomolecules. 2021 Feb; 11(2): 328. |
