For research use only. Not for therapeutic Use.
Ospemifene is an oral medication indicated for the treatment of dyspareunia – pain during sexual intercourse – encountered by some women, more often in those who are post-menopausal. Ospemifene is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen on the vaginal epithelium, building vaginal wall thickness which in turn reduces the pain associated with dyspareunia. Dyspareunia is most commonly caused by /vulval and vaginal atrophy./ The medication was approved by the FDA in February 2013. (Source: http://en.wikipedia.org/wiki/Ospemifene)
Catalog Number | A000148 |
CAS Number | 128607-22-7 |
Synonyms | 128607-22-7; Osphena; FC-1271a; Deamino-hydroxytoremifene; Fc-1271 |
Molecular Formula | C24H23ClO2 |
Purity | ≥95% |
Target | Estrogen Receptor/ERR |
Solubility | >15.4mg/mL in DMSO |
Storage | Store at -20°C |
InChI | 1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23- |
InChIKey | LUMKNAVTFCDUIE-VHXPQNKSSA-N |
SMILES | C1=CC=C(C=C1)C(=C(C2=CC=CC=C2)C3=CC=C(C=C3)OCCO)CCCl |
Reference | 1: Simon JA, Altomare C, Cort S, Jiang W, Pinkerton JV. Overall Safety of 2: Shin JJ, Kim SK, Lee JR, Suh CS. Ospemifene: A Novel Option for the Treatment 3: Schiavi MC, Di Pinto A, Sciuga V, Faiano P, Di Tucci C, D/’oria O, Martoccia A, 4: De Rosa N, Lavitola G, Giampaolino P, Morra I, Nappi C, Bifulco G. Impact of 5: Alvisi S, Baldassarre M, Martelli V, Gava G, Seracchioli R, Meriggiola MC. 6: Schiavi MC, Zullo MA, Faiano P, D/’Oria O, Prata G, Colagiovanni V, Giannini A, 7: Maldonado PA, Montoya TI, Acevedo JF, Keller PW, Word RA. Effects of vaginal 8: Bruyniks N, Biglia N, Palacios S, Mueck AO. Systematic indirect comparison of 9: Kubota R, Matsumoto S, Wajima T. Population pharmacokinetics of ospemifene and 10: Kao CJ, Wurz GT, Lin YC, Vang DP, Phong B, DeGregorio MW. Repurposing |