Osthole

• CAT Number: I003705
• CAS Number: 484-12-8
• Molecular Formula: C15H16O3
• Molecular Weight: 244.30
• Purity: ≥95%
• Synonyms: 7-Methoxy-8-(3-methyl-2-butenyl)coumarin;NSC 31868
• Target: Anticancer; anti-inflammatory
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
• InChI: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
• InChIKey: MBRLOUHOWLUMFF-UHFFFAOYSA-N
• SMILES: CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C

Osthole (Cat No.:I003705) is a natural coumarin derivative found in various medicinal plants, such as Cnidium monnieri and Angelica pubescent. It has been studied for its pharmacological activities and potential therapeutic effects. Osthole exhibits a wide range of biological properties, including anti-inflammatory, antioxidant, anti-cancer, anti-microbial, anti-osteoporotic, and neuroprotective activities. It has shown potential in the treatment of various conditions, including inflammatory disorders, osteoporosis, cancer, cardiovascular diseases, and neurological disorders. Osthole’s mechanisms of action involve the modulation of multiple signaling pathways and targets within the body. Further research is ongoing to explore its therapeutic applications and potential clinical uses.

Reference

[1]. Chen R, et al. Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II. J Pharm Pharm Sci. 2013;16(5):732-41.
[2]. Tang DZ, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun;25(6):1234-45.
[3]. Li Z, et al. Osthole attenuates the development of carrageenan-induced lung inflammation in rats. Int Immunopharmacol. 2014 Feb 24. pii: S1567-5769(14)00067-8.
[4]. Ding D, et al. Osthole exhibits anti-cancer property in rat glioma cells through inhibiting PI3K/Akt and MAPK signaling pathways. Cell Physiol Biochem. 2013;32(6):1751-60.
[5]. Zhang L, et al. Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses. J Ethnopharmacol. 2014 Mar 14;152(2):266-71.