OT-82

• CAT Number: I015470
• CAS Number: 1800487-55-1
• Molecular Formula: C₂₆H₂₁FN₄O
• Molecular Weight: 424.47
• Purity: ≥95%
• Target: Apoptosis
• IUPAC Name: 3-[2-(4-fluorophenyl)ethynyl]-N-[3-(1H-pyrazol-4-yl)propyl]-4-pyridin-4-ylbenzamide
• InChI: InChI=1S/C26H21FN4O/c27-24-8-4-19(5-9-24)3-6-22-16-23(7-10-25(22)21-11-14-28-15-12-21)26(32)29-13-1-2-20-17-30-31-18-20/h4-5,7-12,14-18H,1-2,13H2,(H,29,32)(H,30,31)
• InChIKey: CEPAXRIKSUXHHB-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C#CC2=C(C=CC(=C2)C(=O)NCCCC3=CNN=C3)C4=CC=NC=C4)F

OT-82 (Cat No.:I015470) is a potent, selective, and orally active inhibitor of NAMPT (nicotinamide phosphoribosyltransferase). It exhibits selective toxicity towards cells of hematopoietic origin and induces cell death in an NAD+ (nicotinamide adenine dinucleotide) dependent manner. OT-82 shows promise as an antineoplastic agent for the investigation of hematological malignancies. Its inhibitory activity against NAMPT suggests a potential role in disrupting NAD+ metabolism, a vital pathway for cellular energy regulation and DNA repair. Further research is underway to explore its therapeutic applications in hematological malignancies.

Reference

[1]. Korotchkina L, et al. OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis.Leukemia. 2020 Jan 2.