OT-R antagonist 2

• CAT Number: I003340
• CAS Number: 364071-16-9
• Molecular Formula: C28H29N3O4
• Molecular Weight: 471.557
• Purity: ≥95%
• Target: Oxytocin Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 0.33μM
• IUPAC Name: (2S,4E)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-methoxyimino-1-[4-(2-methylphenyl)benzoyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C28H29N3O4/c1-19-8-6-7-11-24(19)20-12-14-22(15-13-20)28(34)31-18-23(30-35-2)16-25(31)27(33)29-17-26(32)21-9-4-3-5-10-21/h3-15,25-26,32H,16-18H2,1-2H3,(H,29,33)/b30-23+/t25-,26+/m0/s1
• InChIKey: IBXGJPAYWMFXSF-OLFRMSBUSA-N
• SMILES: CC1=CC=CC=C1C2=CC=C(C=C2)C(=O)N3CC(=NOC)CC3C(=O)NCC(C4=CC=CC=C4)O

OT-R antagonist 2 is a nonpeptide low molecular weight OT-R antagonist. OT-R antagonist 2 inhibitis IP3-Synthesis, rat OT-R (IC50 = 0.33 μM).IC50 value: 0.33μMTarget: oxytocin receptor

Reference

[1]. Cirillo R, et al. Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2/’-methyl[1,1/’-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor. J Pharmacol Exp Ther. 2003 Jul;306(1):253-61.

[2]. William Nadler, et al. Method for preparing pyrrolidine oximes. WO/2005082848/A2.

[3]. Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors.WO/2001074769/A1.

[4]. Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors. WO/2001072705/A1.