OTS186935 hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I045837
  • Molecular Formula: C25H26ClN5O2.8/5HCl
  • Molecular Weight: 522.31
  • Purity: ≥95%
Inquiry Now

OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells[1].
OTS186935 hydrochloride inhibits A549 cell growth with an IC50 of 0.67 μM[1].
OTS186935 hydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models[1].


Catalog Number I045837
Molecular Formula C25H26ClN5O2.8/5HCl
Purity ≥95%
Reference

[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.
 [Content Brief]

Request a Quote