OTS514 hydrochloride

• CAT Number: I015575
• CAS Number: 2319647-76-0
• Molecular Formula: C21H20N2O2S.HCl
• Molecular Weight: 400.92
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: Cl.CC(CN)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4

OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.

Reference

[1] Kato T, et al. Oncotarget. 2016, 7(14):17652-64.
[2] Matsuo Y, et al. Sci Transl Med. 2014, 6(259):259ra145.
[3] Ikeda Y, et al. Clin Cancer Res. 2016, 22(24):6110-6117.