OTSSP167 hydrochloride

• CAT Number: I001666
• CAS Number: 1431698-10-0
• Molecular Formula: C25H28Cl2N4O2 • HCl
• Molecular Weight: 523.90
• Purity: ≥95%
• Synonyms: 4-[7-acetyl-8-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1H-1,5-naphthyridin-2-ylidene]-2,6-dichlorocyclohexa-2,5-dien-1-one;hydrochloride
• Target: MELK
• Solubility: DMSO: ≥ 5.6 mg/mL
• Storage: Store at -20C
• IC50: 0.41 nM
• IUPAC Name: 1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone;hydrochloride
• InChI: InChI=1S/C25H28Cl2N4O2.ClH/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3;/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29);1H
• InChIKey: XDGWHISAOWEFML-UHFFFAOYSA-N
• SMILES: CC(=O)C1=CN=C2C=CC(=NC2=C1NC3CCC(CC3)CN(C)C)C4=CC(=C(C(=C4)Cl)O)Cl.Cl

OTSSP167 hydrochloride（Cat No.:I001666）is an investigational small molecule inhibitor of the protein geranylgeranyltransferase I (GGTase-I), which plays a key role in the post-translational modification of proteins involved in cancer cell signaling. By inhibiting GGTase-I, OTSSP167 disrupts the function of oncoproteins, such as Ras and Rho, which are crucial for tumor cell survival and proliferation. The compound is being explored for its potential in treating various cancers, particularly those driven by mutations in Ras or Rho pathways. Currently in clinical trials, its safety, efficacy, and clinical applicability are still being evaluated.