For research use only. Not for therapeutic Use.
OU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a Ki value of 17.6 µM. OU749 shows cytotoxicity[1].
OU749 (compound 3) (3 days) shows cytotoxicity with an LD50 value of 128 µM for 786-O cells[1].
OU749 (0-1000 µM) inhibits GGT (γ-glutamyl transpeptidase) activity in a dose-dependent manner in 786-O and HK-2 cells[1].
| Catalog Number | I011821 |
| CAS Number | 519170-13-9 |
| Synonyms | N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide |
| Molecular Formula | C16H15N3O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H15N3O3S2/c1-22-13-9-7-12(8-10-13)11-15-17-18-16(23-15)19-24(20,21)14-5-3-2-4-6-14/h2-10H,11H2,1H3,(H,18,19) |
| InChIKey | QCXWBMZVLJCKHF-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)CC2=NN=C(S2)NS(=O)(=O)C3=CC=CC=C3 |
| Reference | [1]. King JB, et al. A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase. J Biol Chem. 2009 Apr 3;284(14):9059-65. |
