For research use only. Not for therapeutic Use.
OUL35 (NSC39047) is a potent and selective inhibitor of ARTD10 (PARP-10), with an IC50 of 329 nM[1].
OUL35 rescues HeLa cells from ARTD10-induced cell death and sensitizes cells to DNA damage. OUL35 (3 μM) binds to endogenous ARTD10 in U2OS cells[1].
OUL35 also inhibits ARTD8 (23.4 μM), ARTD4 (22.6 μM), and ARTD15 (4.17 μM) but with modest potency[1].
OUL35 makes hydrogen bonds to the amide and carbonyl of Gly888 and to the side-chain hydroxyl of Ser927. OUL35 stacks between Tyr919 and Tyr932, like 3AB in the crystal structure[1].
| Catalog Number | I011975 |
| CAS Number | 6336-34-1 |
| Synonyms | 4-(4-carbamoylphenoxy)benzamide |
| Molecular Formula | C14H12N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H12N2O3/c15-13(17)9-1-5-11(6-2-9)19-12-7-3-10(4-8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18) |
| InChIKey | XZRCQWLPMXFGHE-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(=O)N)OC2=CC=C(C=C2)C(=O)N |
| Reference | [1]. Harikanth Venkannagari, et al. Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. |
