Oxalomalic Acid (sodium salt)

• CAT Number: R064476
• CAS Number: 89304-26-7
• Molecular Formula: C6H6O8 · 3Na
• Molecular Weight: 275.01
• Purity: ≥95%
• Synonyms: 3-carboxy-3-deoxy-2-pentulosaric acid, trisodium salt
• Target: Isocitrate Dehydrogenase (IDH)
• Storage: -20°C
• InChI: InChI=1S/C6H6O8/c7-2(5(11)12)1(4(9)10)3(8)6(13)14/h1-2,7H,(H,9,10)(H,11,12)(H,13,14)
• InChIKey: YILAUJBAPQXZGM-UHFFFAOYSA-N
• SMILES: OC(C(O)C(C(O)=O)C(C(O)=O)=O)=O

Oxalomalic Acid (sodium salt)(CAT: R064476) is a potent inhibitor of aconitase, an enzyme involved in the citric acid cycle (TCA cycle). By blocking aconitase activity, oxalomalic acid disrupts the conversion of citrate to isocitrate, affecting cellular respiration and energy production. This makes it valuable for research into metabolic pathways, particularly in studying cancer cell metabolism, where altered energy production is a hallmark. Additionally, Oxalomalic Acid (sodium salt) is utilized in investigations related to oxidative stress and mitochondrial dysfunction. Its inhibitory effects on cellular metabolism make it a key tool in understanding energy-related diseases and developing potential therapies.

Reference

1.Gerber, D.E. EGFR inhibition in the treatment of non-small cell lung cancer. Drug Dev. Res. 69(6), 359-372 (2008).