For research use only. Not for therapeutic Use.
Oxantel Pamoate（Cat No.:I004587）is an anthelmintic agent used to treat intestinal worm infections caused by nematodes, particularly Trichuris trichiura (whipworm). It works by acting as a cholinergic agonist, disrupting the parasite’s neuromuscular function, leading to paralysis and expulsion. Oxantel pamoate is often combined with other anthelmintics, such as pyrantel, for broader-spectrum efficacy against multiple worm species. Its targeted action and minimal absorption in the gastrointestinal tract make it safe and effective for both humans and animals. Oxantel pamoate plays a critical role in combating parasitic infections and improving public health.
| Catalog Number | I004587 |
| CAS Number | 68813-55-8 |
| Molecular Formula | C13H16N2O C23H16O6 |
| Purity | ≥95% |
| Target | Parasite |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20C |
| IUPAC Name | 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol |
| InChI | InChI=1S/C23H16O6.C13H16N2O/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-7,10,16H,3,8-9H2,1H3/b;7-6+ |
| InChIKey | CCOAINFUFGBHBA-UETGHTDLSA-N |
| SMILES | CN1CCCN=C1/C=C/C2=CC(=CC=C2)O.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O |
| Reference | </br>1:Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes. Cowan N, Meier C, Neodo A, Keiser J.Int J Parasitol Drugs Drug Resist. 2017 Mar 24;7(2):159-173. doi: 10.1016/j.ijpddr.2017.03.005. [Epub ahead of print] PMID: 28371660 Free PMC Article</br>2:In Vitro and In Vivo Drug Interaction Study of Two Lead Combinations, Oxantel Pamoate plus Albendazole and Albendazole plus Mebendazole, for the Treatment of Soil-Transmitted Helminthiasis. Cowan N, Vargas M, Keiser J.Antimicrob Agents Chemother. 2016 Sep 23;60(10):6127-33. doi: 10.1128/AAC.01217-16. Print 2016 Oct. PMID: 27480864 Free PMC Article</br>3:Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole. Speich B, Moser W, Ali SM, Ame SM, Albonico M, Hattendorf J, Keiser J.Parasit Vectors. 2016 Mar 2;9:123. doi: 10.1186/s13071-016-1406-8. PMID: 26935065 Free PMC Article</br>4:Oxantel pamoate and deworming programmes. Maheu-Giroux M.Lancet Infect Dis. 2016 Jan;16(1):5-6. doi: 10.1016/S1473-3099(15)00305-9. Epub 2015 Sep 18. No abstract available. PMID: 26388170 </br>5:Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study. Moser W, Ali SM, Ame SM, Speich B, Puchkov M, Huwyler J, Albonico M, Hattendorf J, Keiser J.Lancet Infect Dis. 2016 Jan;16(1):53-60. doi: 10.1016/S1473-3099(15)00271-6. Epub 2015 Sep 18. PMID: 26388169 </br>6:Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial. Speich B, Ali SM, Ame SM, Bogoch II, Alles R, Huwyler J, Albonico M, Hattendorf J, Utzinger J, Keiser J.Lancet Infect Dis. 2015 Mar;15(3):277-84. doi: 10.1016/S1473-3099(14)71050-3. Epub 2015 Jan 12. PMID: 25589326 </br>7:Oxantel pamoate-albendazole for Trichuris trichiura infection. McCarthy JS.N Engl J Med. 2014 May 15;370(20):1952-3. doi: 10.1056/NEJMc1403068#SA2. No abstract available. PMID: 24827044 </br>8:Oxantel pamoate-albendazole for Trichuris trichiura infection. Yasukawa K.N Engl J Med. 2014 May 15;370(20):1952. doi: 10.1056/NEJMc1403068#SA1. No abstract available. PMID: 24827043 </br>9:Oxantel pamoate-albendazole for Trichuris trichiura infection. Keiser J, Speich B, Utzinger J.N Engl J Med. 2014 May 15;370(20):1953-4. doi: 10.1056/NEJMc1403068. No abstract available. PMID: 24827042 Free Article</br>10:Oxantel pamoate-albendazole for Trichuris trichiura infection. Speich B, Ame SM, Ali SM, Alles R, Huwyler J, Hattendorf J, Utzinger J, Albonico M, Keiser J.N Engl J Med. 2014 Feb 13;370(7):610-20. doi: 10.1056/NEJMoa1301956. PMID: 24521107 Free Article |
