Oxeladin citrate

For research use only. Not for therapeutic Use.

  • CAT Number: I003917
  • CAS Number: 52432-72-1
  • Molecular Formula: C26H41NO10
  • Molecular Weight: 527.60
  • Purity: ≥95%
Inquiry Now

Oxeladin citrate(Cat No.:I003917)is a drug primarily used as an antitussive (cough suppressant). It works by acting on the central nervous system to suppress the cough reflex, particularly in conditions like dry, non-productive coughs often associated with colds or respiratory infections. Oxeladin is believed to exert its effect by inhibiting the cough center in the brainstem. It is commonly found in combination with other medications in cough syrups or tablets. While generally well tolerated, it should be used with caution in certain populations, and its effectiveness and safety are typically evaluated on a case-by-case basis.


Catalog Number I003917
CAS Number 52432-72-1
Synonyms

Oxeladin citrate; 2-(2-Diethylaminoethoxy)ethyl α,α-diethylphenylacetate

Molecular Formula C26H41NO10
Purity ≥95%
Target Sigma Receptor
Solubility 10 mM in H2O
Storage -20°C
Related CAS 468-61-1(free base)    
IUPAC Name 2-[2-(diethylamino)ethoxy]ethyl 2-ethyl-2-phenylbutanoate;2-hydroxypropane-1,2,3-tricarboxylic acid
InChI InChI=1S/C20H33NO3.C6H8O7/c1-5-20(6-2,18-12-10-9-11-13-18)19(22)24-17-16-23-15-14-21(7-3)8-4;7-3(8)1-6(13,5(11)12)2-4(9)10/h9-13H,5-8,14-17H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey KVKJFNUGVOFNGU-UHFFFAOYSA-N
SMILES CCC(CC)(C1=CC=CC=C1)C(=O)OCCOCCN(CC)CC.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Reference

1: El-Gindy A. High performance liquid chromatographic determination of oxeladin
citrate and oxybutynin hydrochloride and their degradation products. Farmaco.
2005 Aug;60(8):689-99. PubMed PMID: 16023117.
<br>

2: Lartigue-Mattei C, Galmier MJ, Chabard JL, Beyssac E, Aiache JM. Determination
of oxeladin in human plasma by gas chromatography–mass spectrometry. Biomed
Chromatogr. 1995 Jan-Feb;9(1):32-5. PubMed PMID: 7734931.
<br>

3: Knopp C, Korsatko W. [Determination of oxeladin citrate in drug combinations].
Pharmazie. 1982 Jan;37(1):76-7. German. PubMed PMID: 7071116.

<br>
4: Salvesen B, Haugland T. Determination of oxeladin in human sera by gas–liquid
chromatography with thermionic detection. J Chromatogr. 1981 Oct 9;225(2):463-8.
PubMed PMID: 7298782.

<br>
5: Takagi K, Yuizono T, Kasé Y. [On the site of antitussive action of
2-(2-diethylaminoethoxy)ethyl alpha,alpha-diethylphenylacetate (Oxeladin)].
Yakugaku Zasshi. 1967 Aug;87(8):898-906. Japanese. PubMed PMID: 5625837.
<br>

6: OZAWA H, FUKUDA H, OTSUKI I, CHIBA S. [Antitussive activity and acute toxicity
of 2-(2-diethylamino-ethoxy)ethyl alpha,alpha-diethylphenylacetate (oxeladin)].
Yakugaku Zasshi. 1962 Sep;82:1314-7. Japanese. PubMed PMID: 13940888.

<br>
7: DAVID A, LEITH-ROSS F, VALLANCE DK. Antitussive and other pharmacological
properties of the diethylaminoethoxyethyl ester of alpha
alpha-diethylphenylacetic acid, (oxeladin). J Pharm Pharmacol. 1957
Jul;9(7):446-58. PubMed PMID: 13439531.

Request a Quote