OXI-4503 free base

• CAT Number: I034058
• CAS Number: 288847-35-8
• Molecular Formula: C18H22O12P2
• Molecular Weight: 492.31
• Purity: 98%
• Synonyms: OXI-4503; OXI 4503; OXI4503
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: [3-methoxy-2-phosphonooxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
• InChI: InChI=1S/C18H22O12P2/c1-25-13-8-7-12(16(29-31(19,20)21)18(13)30-32(22,23)24)6-5-11-9-14(26-2)17(28-4)15(10-11)27-3/h5-10H,1-4H3,(H2,19,20,21)(H2,22,23,24)/b6-5-
• InChIKey: GSOXMQLWUDQTNT-WAYWQWQTSA-N
• SMILES: COC1=C(C(=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)(O)O)OP(=O)(O)O

OXI-4503 Free Base(CAT: I034058) is a potent vascular-disrupting agent (VDA) that targets tumor vasculature. It acts as a prodrug of combretastatin A1 (CA1), which disrupts the tubulin cytoskeleton of endothelial cells, leading to vascular collapse and tumor necrosis. OXI-4503 also exhibits cytotoxic effects against cancer cells, enhancing its antitumor efficacy. It is widely studied in oncology research for its dual action in inhibiting tumor growth and disrupting the blood supply to solid tumors. This compound is a critical tool for exploring novel therapeutic strategies in cancer treatment, particularly for aggressive and resistant tumor types.