Oxibendazole

For research use only. Not for therapeutic Use.

  • CAT Number: A000352
  • CAS Number: 20559-55-1
  • Molecular Formula: C12H15N3O3
  • Molecular Weight: 249.27
  • Purity: ≥95%
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Oxibendazole(Cat No.:A000352)is a broad-spectrum benzimidazole anthelmintic commonly used to treat parasitic infections in animals, including horses, cattle, and dogs. It works by inhibiting tubulin polymerization, which disrupts the formation of microtubules in parasite cells, leading to impaired cellular functions and eventual death of the parasite. Effective against a range of intestinal worms, such as roundworms, strongyles, and pinworms, oxibendazole is valued for its efficacy and safety in veterinary medicine. Its ability to target parasite microtubules makes it a crucial component in parasite control programs for livestock and pets.


Catalog Number A000352
CAS Number 20559-55-1
Synonyms

20559-55-1; Oxibendazolo; Oxibendazolum; Loditac; Filaribits Plus

Molecular Formula C12H15N3O3
Purity ≥95%
Target DNA polymerase inhibitor
Storage -20°C
IUPAC Name methyl N-(6-propoxy-1H-benzimidazol-2-yl)carbamate
InChI InChI=1S/C12H15N3O3/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChIKey RAOCRURYZCVHMG-UHFFFAOYSA-N
SMILES CCCOC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
Reference

1: Lyons ET, Tolliver SC, Kuzmina TA, Collins SS. Further evaluation in field
tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and
pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight
farms in Central Kentucky (2009-2010). Parasitol Res. 2011 Oct;109(4):1193-7.
doi: 10.1007/s00436-011-2379-3. Epub 2011 Apr 16. PubMed PMID: 21499750.
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2: Traversa D, Iorio R, Otranto D, Giangaspero A, Milillo P, Klei TR.
Species-specific identification of equine cyathostomes resistant to fenbendazole
and susceptible to oxibendazole and moxidectin by macroarray probing. Exp
Parasitol. 2009 Jan;121(1):92-5. doi: 10.1016/j.exppara.2008.10.001. Epub 2008
Oct 8. PubMed PMID: 18950625.

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3: Lyons ET, Tolliver SC, Ionita M, Collins SS. Evaluation of parasiticidal
activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse
foals with emphasis on ascarids (Parascaris equorum) in field studies on five
farms in Central Kentucky in 2007. Parasitol Res. 2008 Jul;103(2):287-91. doi:
10.1007/s00436-008-0966-8. Epub 2008 May 10. PubMed PMID: 18470536.
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4: Magambo JK. Ultrastructural changes in Ascaris suum after oxibendazole
treatment. Afr J Health Sci. 1998 Feb;5(1):38-41. PubMed PMID: 17580993.
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5: Gokbulut C, Nolan AM, McKellar QA. Plasma disposition, faecal excretion and in
vitro metabolism of oxibendazole following oral administration in horses. Res Vet
Sci. 2002 Feb;72(1):11-5. PubMed PMID: 12002632.
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6: Overgaauw PA, Boersema JH. Anthelmintic efficacy of oxibendazole against some
important nematodes in dogs and cats. Vet Q. 1998 Apr;20(2):69-72. PubMed PMID:
9563164.

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7: Gottschall DW, Wang R. Depletion and bioavailability of 14C-oxibendazole
residues in swine tissues. Vet Parasitol. 1996 Aug;64(1-2):83-93. PubMed PMID:
8893466.
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8: Rolfe PF, Dawson KL. The efficacy of a combination anthelmintic against
oxibendazole resistant small strongyles, large strongyles and ascarids in horses.
Aust Vet J. 1994 Sep;71(9):304-6. PubMed PMID: 7818443.
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9: Lyons ET, Drudge JH, Tolliver SC, Swerczek TW, Stamper S, Granstrom DE.
Control of cambendazole-resistant small strongyles (Population S) with
oxibendazole in a pony band: an 8 year field test (1984-1992). Vet Parasitol.
1994 Apr;52(3-4):271-7. PubMed PMID: 8073610.
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10: Tolliver SC, Lyons ET, Drudge JH, Stamper S, Granstrom DE. Critical tests of
thiabendazole, oxibendazole, and oxfendazole for drug resistance of population-B
equine small strongyles (1989 and 1990). Am J Vet Res. 1993 Jun;54(6):908-13.
PubMed PMID: 8323061.

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