For research use only. Not for therapeutic Use.
Oxiconazole Nitrate（Cat No.:R007387）is a broad-spectrum antifungal agent used in the treatment of dermatophyte infections and superficial fungal skin conditions. This azole derivative inhibits fungal ergosterol synthesis by targeting the enzyme lanosterol 14α-demethylase, thereby disrupting the fungal cell membrane integrity. Oxiconazole Nitrate is effective against a range of dermatophytes, yeasts, and molds, making it a valuable therapeutic in both clinical and research settings. It is typically available in topical formulations, offering localized treatment for conditions like athlete’s foot, ringworm, and other skin infections. Ideal for dermatological studies and antifungal resistance research.
| Catalog Number | R007387 |
| CAS Number | 64211-46-7 |
| Synonyms | (Z)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-[(2,4-Dichlorophenyl)methyl]oxime Mononitrate; Sgd-301-76; Ro-13-8996; Myfungar; Oceral; Oxistat; |
| Molecular Formula | C18H13Cl4N3O • HNO3 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | Room temperature |
| IUPAC Name | (Z)-1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine;nitric acid |
| InChI | InChI=1S/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+; |
| InChIKey | WVNOAGNOIPTWPT-NDUABGMUSA-N |
| SMILES | C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-] |
| Reference | </br>1:Oxiconazole nitrate lotion, 1 percent: an effective treatment for tinea pedis. Pariser DM, Pariser RJ.Cutis. 1994 Jul;54(1):43-4. PMID: 7924451 </br>2:Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent. Jegasothy BV, Pakes GE.Clin Ther. 1991 Jan-Feb;13(1):126-41. Review. PMID: 2029718 </br>3:Further in vitro studies with oxiconazole nitrate. Shadomy S, Wang H, Shadomy HJ.Diagn Microbiol Infect Dis. 1988 Apr;9(4):231-7. PMID: 3180708 </br>4:[A contribution to the stereospecific synthesis of antifungal imidazolyloxime-ethers/Oxiconazole nitrate (Sgd 301-76), a new broadspectrum antifungal agent (author/’s transl)]. Mixich G, Thiele K.Arzneimittelforschung. 1979;29(10):1510-3. German. PMID: 583212 |
