Oxidopamine hydrobromide

• CAT Number: I004401
• CAS Number: 636-00-0
• Molecular Formula: C8H11NO3.HBr
• Molecular Weight: 250.09
• Purity: ≥95%
• Synonyms: 5-(2-aminoethyl)benzene-1,2,4-triol hydrobromide
• Target: Dopamine Receptor
• Solubility: DMSO ≥ 29 mg/mL
• Storage: Desiccate at -20C

Oxidopamine hydrobromide (CAT: I004401) is a synthetic compound that is commonly used in research as a neurotoxin to induce the degeneration of dopaminergic neurons. It is structurally similar to dopamine and acts as a selective neurotoxin, specifically targeting dopaminergic neurons in the brain. Oxidopamine hydrobromide is often employed in experimental models to study Parkinson’s disease and related neurodegenerative disorders. By administering oxidopamine hydrobromide, researchers can simulate the loss of dopaminergic neurons seen in Parkinson’s disease, allowing for the investigation of disease mechanisms and the evaluation of potential therapeutic interventions.

Reference

[1]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.

[2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson/’s disease. J Neurochem. 2000 Apr;74(4):1605-12.