For research use only. Not for therapeutic Use.
Oxomemazine（Cat No.:I014893） is a phenothiazine-based compound known for its histamine H1-receptor blocking activity and significant antimuscarinic properties. It acts as a selective antagonist for the muscarinic M1 receptor, exhibiting a high affinity for M1 receptors (Ki = 84 nM) compared to M2 receptors (Ki = 1.65 μM). Oxomemazine is classified as an antihistamine and anticholinergic agent and is commonly used for studying the treatment of cough. By blocking histamine and muscarinic receptors, it helps alleviate symptoms associated with histamine release and excessive cholinergic activity, such as coughing.
| Catalog Number | I014893 |
| CAS Number | 3689-50-7 |
| Molecular Formula | C₁₈H₂₂N₂O₂S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | Store at -20°C |
| IUPAC Name | 3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine |
| InChI | InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3 |
| InChIKey | QTQPVLDZQVPLGV-UHFFFAOYSA-N |
| SMILES | CC(CN1C2=CC=CC=C2S(=O)(=O)C3=CC=CC=C31)CN(C)C |
| Reference | [1]. S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptors.Arch Pharm Res. 1994 Dec;17(6):443-51.<br>[2]. M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67(Pt 8):o1875. |
