Oxonic acid potassium salt

• CAT Number: I002691
• CAS Number: 2207-75-2
• Molecular Formula: C4H2N3O4 • K
• Molecular Weight: 195.2
• Purity: ≥95%
• Synonyms: Allantoxanic Acid;Potassium oxonate
• Target: Endocrine and Metabolic Disease Models
• Solubility: H2O: ≥ 2 mg/mL, DMSO: ＜ 1.9 mg/mL
• Storage: -20°C
• InChIKey: IAPCTXZQXAVYNG-UHFFFAOYSA-M

Oxonic acid potassium salt (CAT: I002691) has been reported as an inhibitor of uricase, an enzyme involved in the metabolism of uric acid. It has been observed to inhibit the phosphorylation of 5-fluorouracil (5-FU) to 5-fluorouridine-5′-monophosphate (5-FUMP) catalyzed by pyrimidine phosphoribosyltransferase (PPRT) in cell-free extracts and intact cells in vitro. This inhibition occurs through a different mechanism compared to allopurinol, another uricase inhibitor. The specific details of the inhibitory mechanism and the potential implications of this activity warrant further investigation and research.

Reference

[1]. Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53(17):4004-9.
[2]. Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26(8):1661-8.