For research use only. Not for therapeutic Use.
Oxybuprocaine（Cat No.:I008526） is an ester-type local anesthetic commonly utilized in ophthalmology and otolaryngology. It exerts its anesthetic effect by binding to sodium channels and reversibly stabilizing the neuronal membrane. By doing so, it reduces the permeability of the membrane to sodium ions, preventing the generation and propagation of action potentials. This results in temporary numbness and loss of sensation in the area where it is applied. Oxybuprocaine is particularly useful for procedures such as eye examinations, minor eye surgeries, and nasal or throat procedures requiring local anesthesia.
| Catalog Number | I008526 |
| CAS Number | 99-43-4 |
| Synonyms | Oxybuprocaine, Benoxinate, BNX, Butoxyprocaine, Novescine, Novesin;2-(diethylamino)ethyl 4-amino-3-butoxybenzoate |
| Molecular Formula | C17H28N2O3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | Room Temperature |
| IUPAC Name | 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate |
| InChI | InChI=1S/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3 |
| InChIKey | CMHHMUWAYWTMGS-UHFFFAOYSA-N |
| SMILES | CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N |
| Reference | </br>1:Comparison of topical oxybuprocaine and intravenous fentanyl in pediatric strabismus surgery. Yousafzai I, Zahoor A, Andrey B, Ahmad N.Saudi J Anaesth. 2017 Jan-Mar;11(1):67-71. doi: 10.4103/1658-354X.197347. PMID: 28217057 Free PMC Article</br>2:Degree of corneal anesthesia after topical application of 0.4% oxybuprocaine ophthalmic solution in normal equids. Little E, Yvorchuk-St Jean K, Little W, Sithole F, St Jean G.Can J Vet Res. 2016 Oct;80(4):329-334. PMID: 27733789 Free PMC Article</br>3:The cytotoxic effect of oxybuprocaine on human corneal epithelial cells by inducing cell cycle arrest and mitochondria-dependent apoptosis. Fan WY, Wang DP, Wen Q, Fan TJ.Hum Exp Toxicol. 2016 Sep 1. pii: 0960327116665676. [Epub ahead of print] PMID: 27590991 </br>4:The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats. Chen YW, Chiu CC, Kan CD, Wang JJ, Hung CH.Reg Anesth Pain Med. 2016 Sep-Oct;41(5):601-6. doi: 10.1097/AAP.0000000000000446. PMID: 27483414 </br>5:Degree of corneal anaesthesia after topical application of 0.4% oxybuprocaine hydrochloride and 0.5% proparacaine hydrochloride ophthalmic solution in clinically normal cattle. Little WB, Jean GS, Sithole F, Little E, Jean KY.Aust Vet J. 2016 Jun;94(6):181-5. doi: 10.1111/avj.12443. PMID: 27237118 </br>6:Corneal thickness differences between sexes after oxybuprocaine eye drops. Fernandez-Garcia P, Cerviño A, Quiles-Guiñau L, Albarran-Diego C, Garcia-Lazaro S, Sanchis-Gimeno JA.Optom Vis Sci. 2015 Jan;92(1):89-94. doi: 10.1097/OPX.0000000000000449. PMID: 25360701 </br>7:Corneal anesthesia following application of 0.4% oxybuprocaine hydrochloride ophthalmic solution to normal feline eyes. Giudici V, Baeza S, Douet JY, Regnier A.Vet Ophthalmol. 2015 Mar;18(2):141-6. doi: 10.1111/vop.12179. Epub 2014 May 14. PMID: 24824864 </br>8:Degree and duration of corneal anesthesia after topical application of 0.4% oxybuprocaine hydrochloride ophthalmic solution in ophthalmically normal dogs. Douet JY, Michel J, Regnier A.Am J Vet Res. 2013 Oct;74(10):1321-6. doi: 10.2460/ajvr.74.10.1321. PMID: 24066916 </br>9:Toxic epitheliopathy from a single application of preservative free oxybuprocaine (0.4%) in a patient with Sjogren/’s syndrome. Ansari H, Weinberg L, Spencer N.BMJ Case Rep. 2013 Sep 13;2013. pii: bcr2013010487. doi: 10.1136/bcr-2013-010487. PMID: 24038291 Free PMC Article</br>10:Comparison of the influence of nonpreserved oxybuprocaine and a preserved artificial tear (thera tears) on human corneal thickness measured by two pachymeters. Almubrad TM, Alshehri FH, Ogbuehi KC, Osuagwu UL.J Ocul Pharmacol Ther. 2013 Jun;29(5):462-8. doi: 10.1089/jop.2012.0215. Epub 2013 Jan 18. PMID: 23331053 |
