Oxymetazoline Hydrochloride

• CAT Number: A000351
• CAS Number: 2315-02-8
• Molecular Formula: C16H24N2O.HCl
• Molecular Weight: 296.84
• Purity: ≥95%
• Synonyms: 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride
• Target: Adrenergic Receptor
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: InChI=1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H
• InChIKey: BEEDODBODQVSIM-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C.Cl

Oxymetazoline Hydrochloride(cas 2315-02-8) is an α1 and α2 adrenergic receptor agonist, used to relieve nasal discomfort caused by colds, allergies, and hay fever.
 It was developed from xylometazoline at E. Merck Darmstadt by Fruhstorfer in 1961.

Reference

1: Stanisz B. The stability of oxymetazoline hydrochloride in aqueous solution.
Acta Pol Pharm. 2002 Jan-Feb;59(1):19-23. PubMed PMID: 12026107.

2: Taverner D, Bickford L, Shakib S, Tonkin A. Evaluation of the dose-response
relationship for intra-nasal oxymetazoline hydrochloride in normal adults. Eur J
Clin Pharmacol. 1999 Sep;55(7):509-13. PubMed PMID: 10501820.

3: Witek TJ Jr, Canestrari DA, Hernandez JR, Miller RD, Yang JY, Riker DK.
Superficial nasal mucosal blood flow and nasal patency following topical
oxymetazoline hydrochloride. Ann Allergy. 1992 Feb;68(2):165-8. PubMed PMID:
1739191.

4: Qualitative and quantitative tests for oxymetazoline hydrochloride. J Pharm
Sci. 1966 Sep;55(9):956-7. PubMed PMID: 5918534.

5: Evaluation of a nasal decongestant. Oxymetazoline hydrochloride (Afrin). JAMA.
1965 Sep 27;193(13):1115. PubMed PMID: 4157497.