For research use only. Not for therapeutic Use.
Oxymetazoline(CAT: M050737) is a medication used as a nasal decongestant and as a topical vasoconstrictor. It works by narrowing the blood vessels in the nasal passages, which helps to relieve congestion and reduce swelling. It is available in various forms, including nasal sprays and drops, as well as in topical creams and gels for use on the skin.
| Catalog Number | M050737 |
| CAS Number | 1491-59-4 |
| Molecular Formula | C16H24N2O |
| Purity | ≥95% |
| Target | α1/α2 adrenergic receptor agonist |
| Storage | -20°C |
| IUPAC Name | 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol |
| InChI | InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18) |
| InChIKey | WYWIFABBXFUGLM-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C |
| Reference | </br>1:Oxymetazoline cream (Rhofade) for rosacea. [No authors listed]Med Lett Drugs Ther. 2017 May 22;59(1521):84-86. No abstract available. PMID: 28520699 </br>2:Intranasal tetracaine and oxymetazoline spray for maxillary local anesthesia without injections. Saraghi M, Hersh EV.Gen Dent. 2017 Mar-Apr;65(2):16-19. No abstract available. PMID: 28253176 </br>3:Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. Liu W, Zhou L, Zeng Q, Luo R.Sci Rep. 2017 Jan 18;7:40425. doi: 10.1038/srep40425. PMID: 28098165 Free PMC Article</br>4:Intranasal tetracaine and oxymetazoline: a newly approved drug formulation that provides maxillary dental anesthesia without needles. Hersh EV, Saraghi M, Moore PA.Curr Med Res Opin. 2016 Oct 3:1-7. [Epub ahead of print] PMID: 27646144 </br>5:Oxymetazoline Metered Dose Spray: Factors Affecting Delivery Volume. Hakim M, Walia H, Rafiq M, Grannell T, Cartabuke RS, Tobias JD.J Pediatr Pharmacol Ther. 2016 May-Jun;21(3):247-51. doi: 10.5863/1551-6776-21.3.247. PMID: 27453703 Free PMC Article</br>6:Population Pharmacokinetics of an Intranasally Administered Combination of Oxymetazoline and Tetracaine in Healthy Volunteers. Cacek AT, Gobburu JV, Gopalakrishnan M.J Clin Pharmacol. 2017 Feb;57(2):247-254. doi: 10.1002/jcph.799. Epub 2016 Aug 23. PMID: 27436060 </br>7:Does oxymetazoline increase the efficacy of nasal steroids in treating nasal polyposis? Kirtsreesakul V, Khanuengkitkong T, Ruttanaphol S.Am J Rhinol Allergy. 2016 May;30(3):195-200. doi: 10.2500/ajra.2016.30.4294. PMID: 27216350 </br>8:Recurrent Apnea in a Neonate Following Intranasal Oxymetazoline. Gopalakrishnan S, Sodhi K.Indian Pediatr. 2016 Apr;53(4):353. No abstract available. PMID: 27156558 Free Article</br>9:Prenatal diagnosis and physical model reconstruction of agnathia-otocephaly with limb deformities (absent ulna, fibula and digits) following maternal exposure to oxymetazoline in the first trimester. Menezes GA, Araujo Júnior E, Lopes J, Belmonte S, Tonni G, Werner H.J Obstet Gynaecol Res. 2016 Aug;42(8):1016-20. doi: 10.1111/jog.13014. Epub 2016 Apr 17. PMID: 27087030 </br>10:The effectiveness of oxymetazoline plus intranasal steroid in the treatment of chronic rhinitis: A randomised controlled trial. Thongngarm T, Assanasen P, Pradubpongsa P, Tantilipikorn P.Asian Pac J Allergy Immunol. 2016 Mar;34(1):30-7. doi: 10.12932/AP0649.34.1.2016. PMID: 26994623 Free Article |
