For research use only. Not for therapeutic Use.
Oxytetracycline Hydrochloride（Cat No.:R065745）is the hydrochloride salt form of oxytetracycline, a tetracycline derivative produced by Streptomyces rimosus exhibiting antimicrobial activity. Oxytetracycline Hydrochloride is an antibacterial compound isolated from the elaboration products of the actinomycete, Streptomyces rimosus, when grown on a suitable medium. Oxytetracycline hydrochloride interferes with binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby preventing peptide elongation and inhibiting protein synthesis. It is often used to treat skin conditions.
| Catalog Number | R065745 |
| CAS Number | 2058-46-0 |
| Molecular Formula | C22H24N2O9•HCl |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | -20°C |
| IUPAC Name | (4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide |
| InChI | InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1 |
| InChIKey | OWFJMIVZYSDULZ-PXOLEDIWSA-N |
| SMILES | C[C@@]1([C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O |
| Reference | </br>1:A novel fluorescent assay for oxytetracycline hydrochloride based on fluorescence quenching of water-soluble CdTe nanocrystals. Gao C, Liu Z, Chen J, Yan Z.Luminescence. 2013 May-Jun;28(3):378-83. doi: 10.1002/bio.2393. Epub 2012 Jun 19. PMID: 22715152 </br>2:Topical 1% oxytetracycline hydrochloride versus placebo in oral mucosa biopsy. López-Jornet P, Camacho-Alonso F, Martinez-Canovas A, Sidrach-Cardona M.Dermatol Surg. 2012 Jul;38(7 Pt 1):1054-8. doi: 10.1111/j.1524-4725.2012.02399.x. Epub 2012 Mar 27. PMID: 22455385 </br>3:Oxytetracycline hydrochloride vital labelling revisited: the case of Dicentrarchus labrax and Diplodus puntazzo. Morales-Nin B, Grau A, Pérez-Mayol S, Pastor E, Palmer M.J Fish Biol. 2011 Mar;78(3):762-82. doi: 10.1111/j.1095-8649.2010.02887.x. PMID: 21366571 </br>4:Clinical, histologic, and bacteriologic findings in dairy cows with digital dermatitis (footwarts) one month after topical treatment with lincomycin hydrochloride or oxytetracycline hydrochloride. Berry SL, Read DH, Walker RL, Famula TR.J Am Vet Med Assoc. 2010 Sep 1;237(5):555-60. doi: 10.2460/javma.237.5.555. PMID: 20807134 </br>5:Determination of oxytetracycline/oxytetracycline hydrochloride in animal feed, fish feed, and veterinary medicinal products by liquid chromatography with fluorescence detection: collaborative study. Thiex NJ, Larson R.J AOAC Int. 2009 Jan-Feb;92(1):2-14. PMID: 19382557 </br>6:Preparation and evaluation of oxytetracycline hydrochloride microbeads for delayed release. Dahiya S, Tyagi L.Pak J Pharm Sci. 2008 Apr;21(2):103-8. PMID: 18390438 </br>7:Reverse micelle-based microencapsulation of oxytetracycline hydrochloride into poly-d,l-lactide-co-glycolide microspheres. Kim H, Lee BJ, Sah H.Drug Deliv. 2007 Feb;14(2):95-9. PMID: 17364873 </br>8:Investigation of Japanese quail (Coturnix japonica) as a pharmacokinetic model for cockatiels (Nymphicus hollandicus) and Poicephalus parrots via comparison of the pharmacokinetics of a single intravenous injection of oxytetracycline hydrochloride. Osofsky A, Tell LA, Kass PH, Wetzlich SE, Nugent-Deal J, Craigmill AL.J Vet Pharmacol Ther. 2005 Dec;28(6):505-13. PMID: 16343282 </br>9:Construction and characterization of potentiometric sensor for the determination of oxytetracycline hydrochloride. Sun XX, Zhang X, Aboul-Enein HY.Farmaco. 2004 Apr;59(4):307-14. PMID: 15081348 </br>10:The dissolution kinetics of sulfamethoxazol, trimethoprim and oxytetracycline hydrochloride from multicomponent solid dispersion capsules (/Sulfoxytrim/). Zuń M, Czarnecki W.Acta Pol Pharm. 2000 Mar-Apr;57(2):97-100. PMID: 10934786 Free Article |
