p-APMSF

• CAT Number: I034212
• CAS Number: 74938-88-8
• Molecular Formula: C8H10ClFN2O2S
• Molecular Weight: 252.69
• Purity: 95%
• Synonyms: p-APMSF, para-APMSF, (p-Amidinophenyl)methanesulfonyl Fluoride
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-(aminoiminomethyl)-benzenemethanesulfonyl fluoride, monohydrochloride
• InChI: InChI=1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H
• InChIKey: KHLLRHIUKOJXLL-UHFFFAOYSA-N
• SMILES: FS(CC1=CC=C(C(N)=N)C=C1)(=O)=O.Cl

p-APMSF (Cat.No:I034212) is a chemical compound used as a serine protease inhibitor. It irreversibly inhibits serine proteases by forming covalent bonds with their active sites. p-APMSF has been widely employed in biochemical and molecular biology research to study serine protease functions and pathways. Its applications include enzyme purification, protein analysis, and protease inhibition studies.

Reference

1. Laura, R., Robison, D.J., and Bing, D.H. (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases. Biochemistry 19(21), 4859-4864 (1980).