P-CAB agent 2

• CAT Number: I041692
• CAS Number: 1978371-23-1
• Molecular Formula: C22H25FN2O4S
• Molecular Weight: 432.51
• Purity: ≥95%
• Synonyms: 1-[5-(2-fluorophenyl)-1-[3-(3-methoxypropoxy)phenyl]sulfonylpyrrol-3-yl]-N-methylmethanamine
• InChI: InChI=1S/C22H25FN2O4S/c1-24-15-17-13-22(20-9-3-4-10-21(20)23)25(16-17)30(26,27)19-8-5-7-18(14-19)29-12-6-11-28-2/h3-5,7-10,13-14,16,24H,6,11-12,15H2,1-2H3
• InChIKey: UDHVRDAZIAGHFG-UHFFFAOYSA-N
• SMILES: CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CC=CC(=C3)OCCCOC

P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].
P-CAB agent 2 (100 µM) inhibits the hERG potassium channel with an inhibition rate of 86.21% and an IC50 value of 18.69 M[1].
P-CAB agent 2 (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats[1].
P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1].

Reference

[1]. YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.